Curso de posgrado sobre estructuras de proteínas

La Fundación Instituto Leloir organiza el curso Análisis, Comparación y Clasificación de Estructuras de Proteínas los días 16 y 17 de diciembre de 2010. El dictado estará a cargo del Dr. Manfred J. Sippl de la Universidad de Salzburg, Austria.

La inscripción puede realizarse hasta el 6 de diciembre enviando el CV y el titulo del proyecto actual de investigacion
cmb@leloir.org.ar. Las plazas son limitadas y se recomienda que quienes poseen laptops las lleven. El costo de inscripción es de $120 para socios de A2B2C, $180 para no socios $180 y gratuita para integrantes del Instituto Leloir.

Programa

Jueves 16 Diciembre (10:00 – 13:00 hrs)
Sesión teórica (10:00-11:20 hrs)
Sesión práctica (11:30-13:00 hrs)

Protein Domains, Facts and Fictions
The concept of protein domains is a recurring topic in bioinformatics. Once you have come across the structure of an immunoglobulin and contemplated its domains you know what we are talking about; once and for all! Well, at least as long as you don’t look at other structures. To get a grip on the problem we will explore a handful of structures in detail, trying to see a common pattern. Only then are we prepared to try a definition of a domain and how to recognize it by computational means. In the practical session you can chop up some proteins yourself to see what you get. There are some surprises ahead.

Jueves 16 Diciembre (15:00 – 18:00 hrs)
Sesión teórica (15:00-16:20 hrs)
Sesión práctica (16:30-18:00 hrs)

Now you see it, now you don’t
A lesson in protein structure comparison Protein Structure research has created a new world. We are sitting on computer screens staring at virtual balls and sticks, ribbons and backbones trying to catch a glimpse of life’s molecular machines in the hope to understand their design, their chemical function, and biological role. We can learn much about the structural logic, inner workings, and evolutionary history of proteins from structure comparison.
Provided the computational tools give us the correct and complete results. The detection of structural relationships among proteins is a tough computational challenge. We will discuss the major problems and how protein structure
superposition can be made to work. In the practical session you can manipulate protein structures and see for yourself.

Viernes 17 Diciembre (10:00 – 13:00 hrs)
Sesión práctica (10:00-13:00 hrs)

How to survive in Fold Space
Today the protein data bank (PDB) contains 70,000 protein files and the non-redundant (NR) data base holds 16,000,000 protein sequences. The numbers double within four years.
Nice, but what can we learn from it? How proteins evolve? How they acquire their specific functions? Do we learn the molecular tricks behind disease relevant mechanisms? Or do we get a deeper understanding of life’s secrets in general? Most certainly yes, provided we learn how to recognize the patterns and rules hidden in the data and how we get quick and reliable answers to our questions. We discuss major challenges and problems in concurrent protein sequence and structure research and focus on practical solutions. In the practical session we work with protein structures in real time. You will have the complete PDB under your fingertips.

Viernes 17 Diciembre (10:00 – 13:00 hrs)
Sesión teórica (15:00-16:30 hrs)

Conferencia:
Desarrollo de nuevas herramientas bioinformáticas para el estudio del proceso de
reconocimiento molecular entre proteínas y ADN.
Francisco Melo, PhD
Laboratorio de Bioinformática Molecular
Facultad de Ciencias Biológicas
P. Universidad Católica de Chile

Viernes 17 de Diciembre (16:30-18 Hrs)
Tiempo dedicado a la interacción con el Profesor Manfred Sippl.

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